Professors at Baylor College and Rice University publish study on genetics
Understanding how rare genetic variations affect the risk of disease is a complicated statistical task that Baylor College of Medicine and Rice University experts are fine-tuning in an attempt to eliminate bias.
In a report in the American Journal of Human Genetics, Dr. Suzanne M. Leal, professor of molecular and human genetics at BCM and Dr. Dajiang J. Liu, of BCM and Rice, described special techniques they had developed that reduce the risk of biasing estimates. Known as the winner's curse, the phenomenon is when rare variants are analyzed in aggregate across a gene region.
In the published study, Leal and co-author Liu note that the contribution of rare variants to particularly inherited traits and/or diseases will always be underestimated for a gene region because some of the variants analyzed in aggregate are not causal and additionally variants within the region may have different magnitudes of effect.
For more information, call 713-798-4011, email firstname.lastname@example.org or visit bcm.edu/genetics/index.cfm?pmid=10939.
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